Markers of protein synthesis are increased in fetal membranes and myometrium after human labour and delivery

S Liong; M Lappas

Journal article

Markers of protein synthesis are increased in fetal membranes and myometrium after human labour and delivery

S Liong, M Lappas

Reproduction Fertility and Development | CSIRO PUBLISHING | Published : 2018

DOI: 10.1071/RD17081

Abstract

Preterm birth remains one of the leading causes of neonatal death. Inflammation and maternal infection are two of the leading aetiological factors for preterm birth. Labour is associated with increased production of proinflammatory cytokines, chemokines and prolabour mediators in human gestational tissues. In non-gestational tissues, synthesis of proinflammatory and prolabour mediators is regulated by components of the protein synthesis machinery. Therefore, in the present study we investigated the effect of human labour on the expression of three protein synthesis markers, namely eukaryotic elongation factor 2 kinase (EEF2K), mitogen-activated protein kinase interacting protein kinase 1 (MK..

View full abstract

University of Melbourne Researchers

Martha Lappas Author

Related Projects (2)

UNDERSTANDING THE MECHANISMS THAT REGULATE INFECTION-INDUCED PRETERM BIRTH

Being born too early is the major cause of perinatal morbidity and mortality and accounts for the majority of neonatal deaths. The aim of th..

UNDERSTANDING WHAT TRIGGERS BIRTH

Being born too early is the major cause of perinatal morbidity and mortality and accounts for the majority of neonatal deaths. The aim of th..

Grants

Awarded by Royal College of Obstetricians and Gynaecologists

Funding Acknowledgements

The authors gratefully acknowledge Gillian Barker (Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, The University of Melbourne) for her excellent technical assistance, clinical research midwives Genevieve Christophers, Gabrielle Pell and Rachel Murdoch for sample collection, and the obstetrics and midwifery staff of the Mercy Hospital for Women for their cooperation. Martha Lappas is supported by a Career Development Fellowship from the Australian National Health and Medical Research Council (NHMRC; Grant no. 1047025). Stella Liong is a recipient of the Glyn White Research Fellowship from the Royal Australian and New Zealand College of Obstetricians and Gynaecologists Research Foundation, an Early Career Researcher Fellowship from The University of Melbourne and a Postdoctoral Award from the Endocrine Society of Australia (ESA). Funding for this study was provided by the NHMRC (Grant no. 1058786) and the Mercy Research Foundation.